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Patents & Patent Applications


Does not include all CIPs, Divisionals or International Patents and Applications.


52. Moreb E.A., Yang, T., and Lynch M.D. Compositions and Methods for CRISPR Enabled DNA Synthesis. US Patent Application No. 62/958,798. Filed: Sept. 1, 2020.

51. Menacho-Melgar, R., and Lynch, M.D. Compositions, Systems, and Methods for High Level Expression of Recombinant Protein. US Patent Application No.: 62/924,898, Filed: Oct 23, 2019.

50. Menacho-Melgar, R., and Lynch, M.D. Compositions and Methods for Autoinducible Cellular Lysis and Nucleotide Hydrolysis. US Patent Application No.: 62/958,806, Filed: Jan 9, 2020

49. Ye, Z. and Lynch, M.D. Methods and Compositions for Improved I-E CRISPR Based Gene Silencing. US Patent Application No.: 62/990,172, Filed: March 16, 2020.

48. Li, S., and Lynch, M.D. Methods and Compositions for the Production of Xylitol From Xylose Utilizing Dynamic Metabolic Control. US Patent Application No.: 63/004,740, Filed: April 3, 2020.

47. Decker, J.S., Menacho-Melgar, and Lynch, M.D. Systems and Method for the Production of Griffithsin and Related Proteins. US Patent Application No.:62/992,557, Filed: March 20, 2020.

46. Li, S. and Lynch, M.D. Methods and Compositions for the Production of Acetyl-CoA Derived Products. US Patent Application No.: 63/056,031, Filed: July 24, 2020.

45. Menacho-Melgar R., Hennigan JN., and Lynch, M.D. Two-stage dynamic control over redox state improves cytosolic expression of disulfide containing proteins in E. coli. US Patent Application No.: 63/177,088., Filed: April 20, 2021.

44. Menacho-Melgar, and Lynch, M.D. Robust Protein Expression Enabled by Dynamic Control Over Host Proteases. US Patent Application No.: 63/064,501, Filed: Aug 12, 2020.

43. Menacho-Melgar, and Lynch, M.D. Rapid Expression and Purification of Thermostable Proteins Including TAQ Polymerase. US Patent Application No.: 63/064,217, Filed: Aug 11, 2020.

42. Lynch, MD., Trahan, AD., Daniel Rodriguez, DL., Ye, Z., Cooper, CB., and Bozdag, A. Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves. US Patent Application No. 16/849,441., Filed: June 11, 2015., Status: Allowed

41. Lynch, MD., Trahan, AD., Daniel Rodriguez, DL., Ye, Z., Cooper, CB., and Bozdag, A. Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves. (3-HP) US Patent Application No. 16/849,441., Filed: June 11, 2015., Status: Allowed

40. Lynch, MD., Trahan, AD., Daniel Rodriguez, DL., Ye, Z., Cooper, CB., and Bozdag, A. Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves. (Alanine) US Patent 11,193,149. Granted: December 7, 2021. Expiration: April 15, 2035.

39. Menacho-Melgar, and Lynch, M.D. In-Vivo Protein N-acylation. US Patent 11,180,739., Granted: Nov 23, 2021., Expiration: April 15, 2035.

38. Lynch, MD., Trahan, AD., Daniel Rodriguez, DL., Ye, Z., Cooper, CB., and Bozdag, A. Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves. (Screening Methods) US Patent 11,142,761., Granted: Oct 12, 2021., Expiration: April 15, 2035.

37. Lynch, MD., Trahan, AD., Daniel Rodriguez, DL., Ye, Z., Cooper, CB., and Bozdag, A. Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves.(Isoprenoid Compositions) US Patent 11,098,307., Date Granted: August 24, 2021., Expiration: June 11, 2035.

36. Lynch, MD., and Ye, Z. Compositions and methods for robust dynamic metabolic control. Japan Patent 6878607., Date Granted: May 6, 2021., Expiration: February 21, 2038.

35. Lynch, MD., Trahan, AD., Daniel Rodriguez, DL., Ye, Z., Cooper, CB., and Bozdag, A. Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves. (Isoprenoid Methods) US Patent 10,662,426., Date Granted: May 26, 2020., Expiration: December 23, 2035.

34. Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, M.D. Acetyl-CoA carboxylases. US Patent 10,155,937., Granted: October, 27, 2020., Expiration: March 17, 2034.

33. Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Acetyl-CoA carboxylases. US Patent 10,815,473., Date Granted: October, 27, 2020. Expiration: March 17, 2034.

32. Liao, H., Spindler, E., Warner, J.R., Louie, M., Ribble, W., Prather, B., Evans, R.E., Lipscomb, T.E., and Lynch, M.D. Microorganisms and methods for the production of fatty acids and fatty acid derived products. US Patent 10,465,213., Granted: Nov 5, 2019., Expiration: August 9, 2033.

31. Ye, Z., and Lynch MD. Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control. US Patent App: 16/448,292., Filed: June 21, 2019. Status (Allowed)

30. Warnecke, TE., Lynch, MD., and Gill, RT. Method for Producing 3-Hydroxypropionic Acid and Other Products. US Patent 10,100,342., Granted: October 16, 2018., Expiration: September 27, 2030.

29. Liao, H., Mercogliano, CP., Wolter, TR., Louie, MT., Ribble, WK., Lipscomb, TE., Spindler, EC., Lynch, MD., Bioproduction of chemicals US Patent: 10,047,383., Date Granted: August, 14, 2018. Expiration: March 17, 2034.

28. Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Acetyl-CoA carboxylases. US Patent 9,447,438., Date Granted: September, 9, 2016. Expiration: March 17, 2034.

27. Lynch, MD., Warnecke, TE., and Gill, RT. Method for Producing 3-Hydroxypropionic Acid and Other Products. US Patent 9,428,778, Granted: Aug 30, 2016., Expiration: Sept. 27, 2030.

26. Gill, RT. Lipscomb, TE., and Lynch, MD. Methods for producing 3-hydroxypropionic acid and other products. US Patent 9,388,419., Date Granted: July, 12, 2016. Expiration: September 30, 2030.

25. Lynch, MD., Gill, RT. and Warnecke, TE. Methods for producing 3-hydroxypropionic acid and other products. US Patent 8,883,464, Date Granted: November 11, 2014., Expiration: Septemebr 27, 2030.

24. Lynch, MD., Mercogliano, CP., Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase. US Patent 8,809,027., Date Granted: August 19, 2014., Expiration: September 10, 2031.

23. Lynch, MD. Compositions and methods for 3-hydroxypropionate bio-production from biomass. Patent Number 8,652,816. Granted: Feb 18, 2014., Expiration: Dec. 4, 2028.

22. Hans L., Spindler, EC> Warner, JR., Louie M., Ribble, W., Prather B., Evans R., Lipscomb TE., Lynch, MD., Micoorganisms and Methods for the Production of Fatty Acids and Fatty Acid Derived Products. Patent App: 13/963,858., Date Filed: August 9, 2013.,

21. Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Bioproduction of chemicals. US Patent App. 14/215,626., Date Filed: March 17, 2014.,

20. Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Monofunctional mcr + 3-hp dehydrogenase US Patent App. 14/215,442., Date Filed: March 17, 2014.,

19. Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Control of growth-induction-production phases. US Patent App. 14/215,508., Date Filed: March 17, 2014.,

18. Gill, RT., Lipscomb, TE., and Lynch, MD. Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes. US Patent 8,467,975., Date Granted: June 18, 2013., Expiration: September 20, 2025.

17. Lynch, MD. Microorganisms and methods for the High Efficiency Conversion of Methane and Methanol to Higher Value Chemicals and Fuels. PCT/US2014/032984., Filed April 4, 2013.

16. Lynch, MD. Compositions and methods for 3-hydroxypropionate bio-production from biomass. US Patent 8,048,624., Date Granted: November 11, 2011., Expiration: December 04, 2028.

15. Lynch, M.D., Warnecke, T.E. and Gill, R.T. Method for Producing 3-Hydroxypropionic Acid and Other Products U.K. Patent GB2473755., Granted: Sept 7, 2011., Expiration: Sept. 27, 2030.

14. Gill, RT., Lipscomb, TE., and Lynch, MD. Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes. US Patent 7,987,056., Date Granted: July 26, 2011., Expiration: February 17, 2027.

13. Gill, RT., Lipscomb, TE., and Lynch, MD. Microorganism production of high-value chemical products, and related compositions, methods and systems. US Patent App: 13/575,581., Date Filed: January 27, 2011.,

12. Lynch, MD., Methods, Systems, and Compositions for Microbial Bio-Production of Biomolecules Using Syngas Components, or Sugars, as Feedstocks US Patent App: 12/950,863. Date Filed: November 19, 2010.,

11. Gill, RT., Lynch, MD. Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria. US Patent: 7,846,688. Date Granted: December 7, 2010., Expiration: September 28, 2028.

10. Lynch, MD. Production of an Organic Acid and/or Related Chemicals. US Patent App. 12/952,149. Filed: November 22, 2010.

9. Gill, RT., Lynch, MD., and Warnecke, TE. Enhanced alcohol tolerant microorganism and methods of use thereof. US Patent: 7,842,485. Date Granted: November 30, 2010., Expiration: October 29, 2028.

8. Warnecke, T.E., Lynch, M.D., and Gill, R.T. Microorganism Production of High-Value Chemical Products, and Related Compositions, Methods and Systems. International Patent Application Number PCT/US2011/022790. Filed: January 27, 2010.

7. Lynch, MD., Mercogliano, CP., Lipscomb, ML., and Lipscomb, TE. Methods, Systems And Compositions Related To Reduction Of Conversions Of Microbially Produced 3-Hydroxyproplonic Acid (3-HP) To Aldehyde Metabolites. US Patent App. 13/062,917. Filed: September 15, 2009.

6. Lynch, MD., Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol. US Patent App. 13/057,359. Filed: August 4, 2009.

5. Gill, RT., Lipscomb, TE., and Lynch, MD. Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp). US Patent App. 13/055,138. Filed: July 23, 2008.

4. Lynch, MD. Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol. US Patent App. 13/002,941. Filed: July 8, 2008.

3. Lynch, MD. Compositions and Methods for enhancing the production of organic chemicals produced by microorganisms. US Patent App. 2008-0103060 A1 Filed: January 12, 2007.

2. Gill, RT., Lipscomb, TE., and Lynch, MD. Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms. US Patent App. 12/523,047. Filed: January 12, 2007.

1. Gill, RT., Lynch, MD., Mills, T. Compositions and methods for chemical reporter vectors. US Patent App. 11/833,879. Filed: August 8, 2006.



Copyright © Michael D. Lynch 2021