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Patents & Patent Applications


  2020



Lynch, MD., Trahan, AD., Daniel Rodriguez, DL., Ye, Z., Cooper, CB., and Bozdag, A. Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves. US Patent 10,662,426., Date Granted: May 26, 2020., Expiration: December 23, 2035.

Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Acetyl-CoA carboxylases. US Patent 10,815,473., Date Granted: October, 27, 2020. Expiration: March 17, 2034.



  2019



Ye, Z., and Lynch MD. Compositions and methods for robust dynamic metabolic control. US Patent App: 16/661,027., Date Filed: August 21, 2019.,

Ye, Z., and Lynch MD. Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control. US Patent App: 16/448,292., Date Filed: June 21, 2019.,



  2018



Liao, H., Mercogliano, CP., Wolter, TR., Louie, MT., Ribble, WK., Lipscomb, TE., Spindler, EC., Lynch, MD., Bioproduction of chemicals US Patent: 10,047,383., Date Granted: August, 14, 2018. Expiration: March 17, 2034.



  2017



Menacho-Melgar, R. and Lynch, MD. In vivo protein n-acylation. US Patent App.: 16/488,973., Filed: February 27, 2017.,



  2016



Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Acetyl-CoA carboxylases. US Patent 9,447,438., Date Granted: September, 9, 2016. Expiration: March 17, 2034.

Gill, RT. Lipscomb, TE., and Lynch, MD. Methods for producing 3-hydroxypropionic acid and other products. US Patent 9,388,419., Date Granted: July, 12, 2016. Expiration: September 30, 2030.



  2015 and Earlier



Lynch, MD., Gill, RT. and Warnecke, TE. Methods for producing 3-hydroxypropionic acid and other products. US Patent 8,883,464, Date Granted: November 11, 2014., Expiration: Septemebr 27, 2030.

Lynch, MD., Mercogliano, CP., Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase. US Patent 8,809,027., Date Granted: August 19, 2014., Expiration: September 10, 2031.

Hans L., Spindler, EC> Warner, JR., Louie M., Ribble, W., Prather B., Evans R., Lipscomb TE., Lynch, MD., Micoorganisms and Methods for the Production of Fatty Acids and Fatty Acid Derived Products. Patent App: 13/963,858., Date Filed: August 9, 2013.,

Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Bioproduction of chemicals. US Patent App. 14/215,626., Date Filed: March 17, 2014.,

Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Monofunctional mcr + 3-hp dehydrogenase US Patent App. 14/215,442., Date Filed: March 17, 2014.,

Liao, H. Mercogliano, CP., Wolter, TR., Louie, MT, Ribble, WK., Lipscomb, TE., Spindler, EC., and Lynch, MD. Control of growth-induction-production phases. US Patent App. 14/215,508., Date Filed: March 17, 2014.,

Gill, RT., Lipscomb, TE., and Lynch, MD. Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes. US Patent 8,467,975., Date Granted: June 18, 2013., Expiration: September 20, 2025.

Lynch, MD. Compositions and methods for 3-hydroxypropionate bio-production from biomass. US Patent 8,048,624., Date Granted: November 11, 2011., Expiration: December 04, 2028.

Gill, RT., Lipscomb, TE., and Lynch, MD. Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes. US Patent 7,987,056., Date Granted: July 26, 2011., Expiration: February 17, 2027.

Gill, RT., Lipscomb, TE., and Lynch, MD. Microorganism production of high-value chemical products, and related compositions, methods and systems. US Patent App: 13/575,581., Date Filed: January 27, 2011.,

Gill, RT., Lynch, MD., and Warnecke, TE. Enhanced alcohol tolerant microorganism and methods of use thereof. US Patent: 7,842,485. Date Granted: November 30, 2010., Expiration: October 29, 2028.

Lynch, MD., Methods, Systems, and Compositions for Microbial Bio-Production of Biomolecules Using Syngas Components, or Sugars, as Feedstocks US Patent App: 12/950,863. Date Filed: November 19, 2010.,

Gill, RT., Lynch, MD. Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria. US Patent: 7,846,688. Date Granted: December 7, 2010., Expiration: September 28, 2028.

Lynch, MD. Production of an Organic Acid and/or Related Chemicals. US Patent App. 12/952,149. Filed: November 22, 2010.

Lynch, MD., Mercogliano, CP., Lipscomb, ML., and Lipscomb, TE. Methods, Systems And Compositions Related To Reduction Of Conversions Of Microbially Produced 3-Hydroxyproplonic Acid (3-HP) To Aldehyde Metabolites. US Patent App. 13/062,917. Filed: September 15, 2009.

Lynch, MD., Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol. US Patent App. 13/057,359. Filed: August 4, 2009.

Gill, RT., Lipscomb, TE., and Lynch, MD. Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp). US Patent App. 13/055,138. Filed: July 23, 2008.

Lynch, MD. Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol. US Patent App. 13/002,941. Filed: July 8, 2008.

Gill, RT., Lipscomb, TE., and Lynch, MD. Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms. US Patent App. 12/523,047. Filed: January 12, 2007.

Gill, RT., Lynch, MD., Mills, T. Compositions and methods for chemical reporter vectors. US Patent App. 11/833,879. Filed: August 8, 2006.



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